N-Methyl-(R)-3-(tert-Butyl)-Sulfinyl-1,4-Dihydropyridine: A Novel NADH Model Compound
oleh: Thomas CW Mak, Yao Fu, Jian-Ge Wang, Yi Cui, You-Cheng Liu, Kun Xie
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2007-03-01 |
Deskripsi
We have synthesized a novel chiral NADH model compound, N-methyl-(R)-3-(tert-butyl)-sulphinyl-1,4-dihydropyridine with high enantioselectivity and used it in the reduction of methyl benzoylformate, producing (S)-methyl mandelate in 95% ee. The absolute structure of its precursor, 3-(tert-butyl)sulfinyl pyridine, was determined by X-ray analysis.