Case Report: Placental Maternal Vascular Malperfusion Affecting Late Fetal Development and Multiorgan Infection Caused by SARS-CoV-2 in Patient With PAI-1 4G/5G Polymorphism
oleh: Behling JAK, Behling JAK, Gabriele Zanirati, Gabriele Zanirati, Felipe V. F. Rodrigues, Felipe V. F. Rodrigues, Matheus Grahl, Matheus Grahl, Felipe Krimberg, Giulia Pinzetta, Larissa Borém, Daniela Savi, Denise Cantarelli Machado, Denise Cantarelli Machado, Denise Cantarelli Machado, Jaderson Costa Da Costa, Jaderson Costa Da Costa, Jaderson Costa Da Costa, Daniel Rodrigo Marinowic, Daniel Rodrigo Marinowic, Daniel Rodrigo Marinowic, Daniel Rodrigo Marinowic
| Format: | Article |
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| Diterbitkan: | Frontiers Media S.A. 2021-02-01 |
Deskripsi
Background: Pregnant women are susceptible to the novel coronavirus (SARS-CoV-2), and the consequences for the fetus are still uncertain. Here, we present a case of a pregnant woman with subclinical hypothyroidism and a plasminogen activator inhibitor type 1 (PAI-1) 4G/5G polymorphism who was infected with SARS-CoV-2 at the end of the third trimester of pregnancy, with unexpected evolution of death of the newborn 4 days postpartum.Methods: Nested PCR was performed to detect the virus, followed by ssDNA sequencing.Results: Transplacental transmission of SARS-CoV-2 can cause placental inflammation, ischemia, and neonatal viremia, with complications such as preterm labor and damage to the placental barrier in patients with PAI-1 4G/5G polymorphism.Conclusion: We showed a newborn with several damages potentially caused due to the PAI-1 polymorphisms carried by the mother infected with SARS-CoV-2 during pregnancy.