Cobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids
oleh: Xiaoyong Du, Ye Xiao, Jia-Ming Huang, Yao Zhang, Ya-Nan Duan, Heng Wang, Chuan Shi, Gen-Qiang Chen, Xumu Zhang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-06-01 |
Deskripsi
A large number of marketed drugs contains a chiral carboxylic acid scaffold. Here, the authors report the asymmetric hydrogenation of α,β-unsaturated carboxylic acids to α-chiral carboxylic acids using a cobalt catalyst bearing an electron-donating chiral diphosphine ligand.