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AIM: To explore the clinical significances and changes of related parameters of corneal endothelial cell in keratouveitis patients before and after treatment.<p>METHODS:Fifty-two keratouveitis patients(52 eyes)diagnosed and treated in our hospital from October 2012 to December 2013 were collected. Before and after treatment, the related parameters of corneal endothelial cell in all patients were measured with non-contact corneal specular microscope and these parameters were statistically analyzed. <p>RESULTS: Compared with the normal group, obvious endothelial cell edema and great variation was observed in diseased group. The shorter duration of treatment, the better the recovery of endothelial cells and the fewer cells lose. Conversely, the longer the healing of normal hexagonal cell ratio was smaller, the larger the coefficient of variation. Before and after treatment, the differences of each parameter were statistical significance(<i>P</i><0.05).<p>CONCLUSION: The functional recovery of corneal endothelial cell has directly relation with disease times.