A benzodiazepine activator locks Kv7.1 channels open by electro-mechanical uncoupling
oleh: Julian A. Schreiber, Melina Möller, Mark Zaydman, Lu Zhao, Zachary Beller, Sebastian Becker, Nadine Ritter, Panpan Hou, Jingyi Shi, Jon Silva, Eva Wrobel, Nathalie Strutz-Seebohm, Niels Decher, Nicole Schmitt, Sven G. Meuth, Martina Düfer, Bernhard Wünsch, Jianmin Cui, Guiscard Seebohm
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-04-01 |
Deskripsi
The binding site and mechanism of action for a benzodiazepine-derivative agonist on Kv7.1 channels is determined for drug development to treat long QT syndrome.