Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling
oleh: Amy K. Rines, Hsiang-Chun Chang, Rongxue Wu, Tatsuya Sato, Arineh Khechaduri, Hidemichi Kouzu, Jason Shapiro, Meng Shang, Michael A. Burke, Eltyeb Abdelwahid, Xinghang Jiang, Chunlei Chen, Tenley A. Rawlings, Gary D. Lopaschuk, Paul T. Schumacker, E. Dale Abel, Hossein Ardehali
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-01-01 |
Deskripsi
The Snf1-related kinase (SNRK) is widely expressed and yet its function is poorly understood. Here the authors show that SNRK regulates mitochondrial coupling via the Trib3-PPARĪ±-UCP3 pathway and that cardiac overexpression of SNRK decreases metabolic substrate usage and oxygen consumption but maintains cardiac function and energy in mice.