Evolution and activation mechanism of the flavivirus class II membrane-fusion machinery
oleh: Marie-Christine Vaney, Mariano Dellarole, Stéphane Duquerroy, Iris Medits, Georgios Tsouchnikas, Alexander Rouvinski, Patrick England, Karin Stiasny, Franz X. Heinz, Félix A. Rey
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-06-01 |
Deskripsi
The mechanism of flavivirus activation for membrane fusion is not yet understood. Here, Vaney et al. describe how the viral pr protein, derived from an HSP40/DnaJ chaperonin, interacts with a pH sensing loop in the envelope protein E for fusogenic activation.