Generation of human induced pluripotent stem cell lines from two patients affected by catecholamine-induced QT prolongation (CIQTP)

oleh: Bastien Cimarosti, Robin Canac, Aurore Girardeau, Marine Arnaud, Quentin Francheteau, Vincent Probst, Patricia Lemarchand, Richard Redon, Jean-Baptiste Gourraud, Nathalie Gaborit, Guillaume Lamirault

Format: Article
Diterbitkan: Elsevier 2022-03-01

Deskripsi

Catecholamine-induced QT prolongation (CIQTP) is an inherited cardiac disease characterized by a normal baseline ECG and a risk of sudden cardiac death by ventricular arrhythmia due to a QT prolongation that only appears during catecholergic stimulation, especially mental stress. Induced pluripotent stem cells (hiPSCs) were generated from peripheral blood mononuclear cells collected from two CIQTP-affected patients from two different families. These two hiPSC lines are a valuable model to study biological alterations due to CIQTP.