An Igh distal enhancer modulates antigen receptor diversity by determining locus conformation
oleh: Khalid H. Bhat, Saurabh Priyadarshi, Sarah Naiyer, Xinyan Qu, Hammad Farooq, Eden Kleiman, Jeffery Xu, Xue Lei, Jose F. Cantillo, Robert Wuerffel, Nicole Baumgarth, Jie Liang, Ann J. Feeney, Amy L. Kenter
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-03-01 |
Deskripsi
Here the authors show enhancers in the Igh locus play a major role in configuring locus architecture and in V(D)J recombination, and identify a link between enhancer hub formation, locus contraction and cohesin-mediated loop extrusion.