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Towards an Early Clinical and Biological Resistance Detection in Dermatophytosis: About 2 Cases of <i>Trichophyton indotineae</i>
oleh: Giuseppe Russo, Laurence Toutous Trellu, Lionel Fontao, Béatrice Ninet
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2023-07-01 |
Deskripsi
<i>Trichophyton indotineae</i> causes resistant dermatophytosis to terbinafine. The global spread of terbinafine-resistant <i>Trichophyton indotineae</i> strains with mutations in the squalene epoxidase gene is a major issue. This emerging species is now more frequently isolated in Europe and we report here two cases of <i>T. indotineae</i> tinea corporis in Switzerland, one with in vitro resistance to terbinafine and a second with in vitro susceptibility but a clinical resistance. Mycology isolation from cultures and sequencing ITS gene were used to confirm <i>T. indotineae</i> infection. In vitro antifungal susceptibility was tested in a microplate with a colorimetric detection of fungal viability for the determination of the minimal inhibitory concentration (MIC). Facing these emerging resistances and since there are a limited number of antifungal agents available to treat dermatophytosis, the early detection of terbinafine resistance should be a prerequisite in the management of <i>T. indotineae</i> infections.