Human platelets antigens influence the viral load of platelets after the interaction of the platelets with HCV and HIV in vitro
oleh: Rejane Maria Tommasini Grotto, Natália Mirele Cantão, Juliana Lara Padovani, Lenice do Rosário de Souza, Giovanni Faria Silva, Adriana Camargo Ferrasi, Maria Inês de Moura Campos Pardini
| Format: | Article |
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| Diterbitkan: | Sociedade Brasileira de Medicina Tropical (SBMT) |
Deskripsi
Abstract: INTRODUCTION: In this study, we evaluated hepatitis C virus (HCV) and human immunodeficiency virus (HIV) - platelet interactions in vitro as well as human platelets antigen (HPA) polymorphisms. METHODS: Platelets were obtained from 100 healthy HPA-genotyped volunteer donors and incubated with HIV or HCV. The viral load after in vitro exposure was detected. RESULTS: The viral load in the platelets after exposure to the virus was higher in the HIV exposure than in the HCV exposure. CONCLUSIONS: HIV-platelet ligation could be more efficient than HCV-platelet interaction. Further, the HPA-1b allele seems to influence the interaction of platelets with HCV.