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Prosthetic joint infection is an uncommon entity, but it supposes high costs, both from the economic side to the health systems and from the emotional side of the patient. The evaluation of the bacterial adherence to different materials frequently involved in joint prostheses allows us to better understand the mechanisms underlying this and provide information for the future development of prevention strategies. This study evaluated the bacterial adherence of four different species (<i>Staphylococcus aureus</i>, <i>Staphylococcus epidermidis</i>, <i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i>) on Ti6Al4V and CoCrMo. The topography, surface contact angles, and linear average roughness were measured in the samples from both alloys. The interaction with the surface of both alloys was significantly different, with the CoCrMo showing an aggregating effect on all the species, with additional anti-adherent activity in the case of <i>Pseudomonas aeruginosa</i>. The viability also changes, with a significant decrease (<i>p</i> < 0.05) in the CoCrMo alloy. In the case of <i>S. epidermidis,</i> the viability in the supernatant from the samples was different, too, with a decrease in the colony-forming units in the Ti6Al4V, which could be related to cation release from the surface. Beyond adhesion is a multifactorial and complex process, and considering that topography and wettability were similar, the chemical composition could play a main role in the different properties observed.