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Abstract Aim The current work investigated the issues that cause apprehension in infertile women, the effects of this disquiet on their quality of life and the strategies that they adopt in dealing with their concerns. Design The qualitative research. Method This qualitative research sampled participants from a training centre in Mazandaran University of Medical Sciences and a privately owned infertility centre in Mazandaran Province, north of Iran. Purposive sampling continued until data saturation was reached. We conducted a conventional content analysis of the responses of 30 individuals (15 women with female infertility and 15 key informants) to in‐depth and semi‐structured in‐person interviews on May to November 2019 . Results The results uncovered two themes subsuming four categories of issues: The first theme revolves around “infertility concerns,” under which “concerns” and “the difficulty and vagueness of treatment” belonged. The second theme was “dealing with infertility,” which covered “adaptive strategies” and “inhibitors of reconciliation with perceived infertility.”