Research progress on the role of myocardial cell calcium homeostasis dysregulation in heart failure
oleh: LIU Feng-yu, HAN Wei
| Format: | Article |
|---|---|
| Diterbitkan: | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. 2022-03-01 |
Deskripsi
Calcium homeostasis of cardiomyocytes depends on the regulation of calcium(Ca2+) transportation through plasma membrane, sarco/endoplasmic reticulum(SR) and mitochondria. One of the main characteristics of heart failure is calcium homeostasis, including cytosolic calcium overload and SR calcium leakage, which leads to transient decrease of myocardial calcium and decrease of contractility.