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AIM: To compare the clinical curative effect with lucentis and photodynamic therapy in the disease of wet age-related macular degeneration. <p>METHODS: A retrospective study in 23 cases with photodynamic therapy(PDT),and another 23 patients who were injected lucentis. We compared the results of best corrected visual acuity, OCT and FFA after 1mo, 3mo and 6mo. <p>RESULTS: Both groups had a great significant improvement in best corrected acuity visual at 1mo and 3mo later. The comparison between the two groups had no statistical significance. But the best corrected visual acuity in 2 patients(9%)of lucentis group was lower at 6mo than at 1mo and 3mo.<p>CONCLUSION: The study showed the two methods for treating wet age-related macular degeneration were effective in short time, but the stability at 6mo of PDT group was better than lucentis group.