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<!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:PunctuationKerning/> <w:ValidateAgainstSchemas/> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:Compatibility> <w:BreakWrappedTables/> <w:SnapToGridInCell/> <w:WrapTextWithPunct/> <w:UseAsianBreakRules/> <w:DontGrowAutofit/> </w:Compatibility> <w:BrowserLevel>MicrosoftInternetExplorer4</w:BrowserLevel> </w:WordDocument> </xml><![endif]--><!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" LatentStyleCount="156"> </w:LatentStyles> </xml><![endif]--> <!-- /* Font Definitions */ @font-face {font-family:Calibri; panose-1:2 15 5 2 2 2 4 3 2 4; mso-font-charset:0; mso-generic-font-family:swiss; mso-font-pitch:variable; mso-font-signature:-1610611985 1073750139 0 0 159 0;} @font-face {font-family:Constantia; panose-1:2 3 6 2 5 3 6 3 3 3; mso-font-charset:0; mso-generic-font-family:roman; mso-font-pitch:variable; mso-font-signature:-1610611985 1073750091 0 0 159 0;} /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:""; margin-top:0cm; margin-right:0cm; margin-bottom:10.0pt; margin-left:0cm; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Times New Roman"; mso-fareast-font-family:Calibri;} @page Section1 {size:612.0pt 792.0pt; margin:72.0pt 90.0pt 72.0pt 90.0pt; mso-header-margin:36.0pt; mso-footer-margin:36.0pt; mso-paper-source:0;} div.Section1 {page:Section1;} --> <!--[if gte mso 10]> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} </style> <![endif]--> <p style="text-align: justify; line-height: 200%" class="MsoNormal"><span style="font-size: 12pt; line-height: 200%">Background: Health related quality of life is considered to be an important outcome measure in studies involving patients with chronic neurological conditions such as Parkinson’s disease. Disease specific patient reported outcome measures(PROMs) are increasingly used as primary end points in clinical trials of new treatments for such conditions. The most widely used disease specific PROM in PD is the 39 item Parkinson's Disease Questionnaire (PDQ-39). The aim of this study was to determine validity and reliability of Persian PDQ-39. </span></p> <p style="text-align: justify; line-height: 200%" class="MsoNormal"><span style="font-size: 12pt; line-height: 200%">Methods: Two hundred and forty Parkinson’s disease patients attending neurologic clinics of<span>  </span>teaching hospitals were recruited. PD patients completed a translated version of the PDQ-39 after giving informed consent. Internal consistency reliability of the questionnaire was assessed by Cronbach's alpha coefficient. Reproducibility (test/retest reliability) was assessed across the 3-week interval<span>  </span>using the intraclass correlation coefficient (ICC). To assess convergent validity, results on the PDQ-39 were correlated with those gained on the SF-36, a widely used generic outcome measure. Discriminate validity of<span>  </span>questionnaire were assessed by comparing<span>  </span>PDQ-39 scores and the severity and the duration of disease.</span></p> <p style="text-align: justify; line-height: 200%" class="MsoNormal"><span style="font-size: 12pt; line-height: 200%">Results: A value of 0.93 (Cronbach’s </span><span style="font-size: 12pt; line-height: 200%; font-family: Constantia">α)</span><span style="font-size: 12pt; line-height: 200%"> was gained for the summary score (PDQ-SI), indicating high levels of internal reliability. Alpha value of seven of the eight 8 domains was greater than 0.70. The intraclass correlation coefficient (ICC) ranged 0.47 to 0.90. The range of correlation coefficients between domains of<span>  </span>SF-36 and PDQ-SI<span>  </span>was -0.40 to -0.61. There was a statistically significant difference between severity of disease and mean scores of PDSI.</span></p> <p style="text-align: justify; line-height: 200%" class="MsoNormal"><span style="font-size: 12pt; line-height: 200%">Conclusion: This study provides evidence that the Persian version of PDQ-39 is valid and reliable measure of quality of life in PD.<span>  </span></span></p> <p style="text-align: justify; line-height: 200%" class="MsoNormal"><span style="font-size: 12pt; line-height: 200%">Key words: Parkinson’s disease; Quality of life; Patient reported outcomes measures; PDQ-39; Validity; Reliability</span></p>