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Eco-friendly synthesis of some selected Barbiturates, Thiobarbiturates and Dimedone derivatives has been developed by using task specific ionic liquid Bmim[OH], which not only act as catalyst but also  are best solvent media for the Knoevenagel condensation reaction between heteroaryl (pyrazole, 2-chloro-quinoline and Indole) aldehydes with barbituric/ thiobarbituric acid and dimedone. High yield and less reaction time are the advantages of this methodology. All the synthesized compounds were tested for their antimicrobial activities. Most of the compounds showed very good antibacterial and antifungal activity. DOI: http://dx.doi.org/10.17807/orbital.v11i3.1175