Prospective Activity of PLG0206, an Engineered Antimicrobial Peptide, on Chronic Periprosthetic Joint Infection Total Knee Arthroplasty Components Ex Vivo: The Knee Explant Analysis (KnEA) Study
oleh: David Huang, Dana M. Parker, Jonathan B. Mandell, Kimberly M. Brothers, Charles G. Gish, John A. Koch, Nicholas Pachuda, Despina Dobbins, Jonathan Steckbeck, Kenneth L. Urish
| Format: | Article |
|---|---|
| Diterbitkan: | American Society for Microbiology 2021-12-01 |
Deskripsi
ABSTRACT PLG0206 is an engineered antimicrobial peptide that has completed phase 1 clinical studies. A prospective study was completed on explanted implants from chronic periprosthetic joint infections (n = 17). At a concentration of 1 mg/mL for 15 min, there was a mean 4-log10 reduction (range, 1 to 7) in the bacterial CFU identified from the implants. IMPORTANCE Chronically infected prosthetics of the knee were exposed to PLG0206, an engineered antimicrobial peptide, at a concentration of 1 mg/mL for 15 min. A mean 4-log10 reduction (range, 1 to 7) in the number of bacteria occurred, which may translate to improved clinical outcomes for persons with prosthetic joint infection of the knee.