IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes
oleh: Olivia J. James, Maud Vandereyken, Julia M. Marchingo, Francois Singh, Susan E. Bray, Jamie Wilson, Andrew G. Love, Mahima Swamy
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-07-01 |
Deskripsi
Intraepithelial lymphocytes (IEL) respond to IL-15 complexed with IL-15Ra but how this intrinsically affects IEL is unclear. Here the authors use proteomics analyses of the main mouse IEL subsets and identify PIM kinases as essential for IEL proliferation, metabolism and effector function downstream of IL-15.