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A gain slab configuration with a low thermally induced wavefront distortion, which is based on heating the edge by the cladding layer, is proposed. The gain slab will be applied to a helium-cooled Nd: glass multislab laser amplifier with an output of 100 J at a repetition rate of 10 Hz. Additionally, a 3D numerical simulation model is developed to analyze the thermo-optic effects in the gain slab. Some parameters, including the absorption coefficient (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi>α</mi></semantics></math></inline-formula>) of the cladding layer, the shape of the pump beam, and the gap between the pump area and absorbing cladding layer, are optimized to eliminate the thermo-optic effects. The results indicate that the peak-to-valley (P-V) of the thermally induced wavefront distortion of the specific gain slab can be reduced by 61% if other parameters remain constant.