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This research has been investigated water pressure drop through the multistage industrial orifices that are installed into a pipe in 1300 MW Arak-Shazand Thermal Power Plant. Whereas having turbulence flow done simulating model was standard . In order to reach a specific water pressure drop with a specific water flow rate, the optimum design is implemented based on the composition of orifice stageâs number along with changing the diameter of the holes and numberâs. Finally to verification of simulationâs results, it will be compared with results of experimental test that is done with multistage orifices installed into a pipe. That could be illustrated good adjustment with together. Also this pressure drop lead to increase the percentageâs opening spray control valves that has extreme influence to decrease corrosion and better work of control valves.