Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration
oleh: Richard Gordon, Matthew L. Neal, Jie Luo, Monica R. Langley, Dilshan S. Harischandra, Nikhil Panicker, Adhithiya Charli, Huajun Jin, Vellareddy Anantharam, Trent M. Woodruff, Qun-Yong Zhou, Anumantha G. Kanthasamy, Arthi Kanthasamy
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-10-01 |
Deskripsi
Prokineticin-2 (PK2) is a secreted protein involved in a number of physiological functions. Here, the authors find that PK2 expression increases in surviving DA neurons from Parkinson's disease patients, and show it protects against dopaminergic degeneration in PD mouse models.