Find in Library
Search millions of books, articles, and more
Indexed Open Access Databases
Pathogenicity and Virulence of Legionella: Intracellular replication and host response
oleh: Deepika Chauhan, Stephanie R. Shames
Format: | Article |
---|---|
Diterbitkan: | Taylor & Francis Group 2021-12-01 |
Deskripsi
Bacteria of the genus Legionella are natural pathogens of amoebae that can cause a severe pneumonia in humans called Legionnaires’ Disease. Human disease results from inhalation of Legionella-contaminated aerosols and subsequent bacterial replication within alveolar macrophages. Legionella pathogenicity in humans has resulted from extensive co-evolution with diverse genera of amoebae. To replicate intracellularly, Legionella generates a replication-permissive compartment called the Legionella-containing vacuole (LCV) through the concerted action of hundreds of Dot/Icm-translocated effector proteins. In this review, we present a collective overview of Legionella pathogenicity including infection mechanisms, secretion systems, and translocated effector function. We also discuss innate and adaptive immune responses to L. pneumophila, the implications of Legionella genome diversity and future avenues for the field.