Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding
oleh: Wenting Liu, Yi-Fang Zhong, Liu-Yi Liu, Chu-Tong Shen, Wenjuan Zeng, Fuyi Wang, Danzhou Yang, Zong-Wan Mao
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-08-01 |
Deskripsi
DNA G-quadruplexes occur in oncologically relevant regions, thus are interesting targets for cancer research and treatment. Here, the authors solved the 1:1 and 4:2 (ligand/DNA) NMR structures of human telomeric DNA in complex with platinum(II)-tripod ligand and show that the binding is dynamic.