p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs
oleh: Hye Yeon Choi, Hifzur R. Siddique, Mengmei Zheng, Yi Kou, Da-Wei Yeh, Tatsuya Machida, Chia-Lin Chen, Dinesh Babu Uthaya Kumar, Vasu Punj, Peleg Winer, Alejandro Pita, Linda Sher, Stanley M. Tahara, Ratna B. Ray, Chengyu Liang, Lin Chen, Hidekazu Tsukamoto, Keigo Machida
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-06-01 |
Deskripsi
Normal stem cells are maintained by asymmetric cell division, but this process is dysregulated in tumour initiating stem-like cells (TICs). Here, the authors show that TBC1D15 impairs the asymmetric division machinery and activates NOTCH pathway for TIC self-renewal and expansion to promote liver tumorigenesis.