Targeting QKI-7 in vivo restores endothelial cell function in diabetes
oleh: Chunbo Yang, Magdalini Eleftheriadou, Sophia Kelaini, Thomas Morrison, Marta Vilà González, Rachel Caines, Nicola Edwards, Andrew Yacoub, Kevin Edgar, Arya Moez, Aleksandar Ivetic, Anna Zampetaki, Lingfang Zeng, Fiona L. Wilkinson, Noemi Lois, Alan W. Stitt, David J. Grieve, Andriana Margariti
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-07-01 |
Deskripsi
Vascular endothelial cell (EC) dysfunction contributes to the occurrence of diabetic complications. Here the authors report that in diabetic conditions, upregulation of the RNA binding protein QKI-7 in ECs due to the imbalance of RNA splicing factors CUG-BP and hnRNPM contributes to EC dysfunction, and that in vivo QKI-7 silencing improves blood flow recovery in diabetic mice with limb ischemia.