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<p> </p><p><strong>Objective</strong> To establish database for brain tumor patients with mood disorders and to explore the status and epidemiological characteristics of emotional function. <strong>Methods </strong> By using computer software, establish database of brain tumor with affective disorder based on clinical requirements. Record the data of 140 cases of brain tumors undergoing operation treatment, so as to found perfect public data platform and realize resource sharing. <strong>Results</strong> The clinical data of 140 brain tumor patients were successfully filled in the registration query system. The database provides simple and complex mood data queries for users to browse. <strong>Conclusions</strong> The mood disorder database for patients with brain tumors can provide related data samples and resources for basic and clinical research. Besides, it can effectively share clinical research data and reduce research costs.</p><p> </p><p><strong>DOI: </strong>10.3969/j.issn.1672-6731.2015.09.010</p>