Enantioselective cyanation via radical-mediated C–C single bond cleavage for synthesis of chiral dinitriles
oleh: Tao Wang, Yi-Ning Wang, Rui Wang, Bo-Chao Zhang, Chi Yang, Yan-Lin Li, Xi-Sheng Wang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-11-01 |
Deskripsi
Ring-opening reaction via selective cleavage of C–C bond is a powerful strategy to increase molecular complexity. Here the authors present the facile synthesis of chiral 1,5- and 1,6-dinitriles via the radical-mediated ring-opening and enantioselective cyanation of cycloketone oxime esters.