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Compassionate Use of Cefiderocol to Treat a Case of Prosthetic Joint Infection Due to Extensively Drug-Resistant <i>Enterobacter hormaechei</i>
oleh: Soline Siméon, Laurent Dortet, Frédérique Bouchand, Anne-Laure Roux, Rémy A. Bonnin, Clara Duran, Jean-Winoc Decousser, Simon Bessis, Benjamin Davido, Grégory Sorriaux, Aurélien Dinh
Format: | Article |
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Diterbitkan: | MDPI AG 2020-08-01 |
Deskripsi
We report the case of a 67-year old man with a right knee prosthetic joint infection due to extensively drug-resistant <i>Enterobacter hormaechei</i>. The resistance phenotype was due to the overproduction of the intrinsic cephalosporinase (ACT-5) associated with the production of three acquired β-lactamases (CTX-M-15, TEM-1B and OXA-1), and a putative membrane decreased permeability. He was first treated with colistin-tigecyclin due to adverse drug reactions; treatment was switched to cefiderocol for a 12-week antibiotic duration, with a favorable outcome.