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Glioma is the most common malignant tumor of the central nervous system, and it isdifficult to cure. The growth of malignant glioma is invasive. In recent decades, the strategy of surgicalresection combined with concurrent radiotherapy and chemotheraphy, and immunocheckpoint inhibitorshave been made progress. However, the therapeutic effect is still not ideal, which may be related to the lowimmunogenicity of tumor cells and the immunosuppression of tumor microenvironment (TME). In the TME,immune cells compete with glioma cells and other proliferating cells for nutrients, while metabolites in theTME affect the differentiation and functions of immune cells. This article summarizes the research progressof glioma metabolism regulation and tumor immunosuppressive microenvironment in recent years, whichprovides new ideas for the study of the mechanism of tumor progression and glioma of treatment. DOI:10.3969/j.issn.1672-6731.2020.02.002