NCLX prevents cell death during adrenergic activation of the brown adipose tissue
oleh: Essam A. Assali, Anthony E. Jones, Michaela Veliova, Rebeca Acín-Pérez, Mahmoud Taha, Nathanael Miller, Michaël Shum, Marcus F. Oliveira, Guy Las, Marc Liesa, Israel Sekler, Orian S. Shirihai
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-07-01 |
Deskripsi
Brown adipose tissue activation of thermogenesis is accompanied by a sequence of events commonly associated with apoptosis, however they evade cell death. Assali et al. show that NCLX prevents mitochondrial calcium overload and apoptosis. Deletion of NCLX, converts a thermogenic signal into a death pathway.