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A devastating earthquake of magnitude 6.9 occurred in Southern Italy on 23rd November 1980 in Irpinia-Basilicata
 area. Variations of different geochemical, atmospheric and ionospheric parameters and electromagnetic emissions
 were registered around the time of the Irpinia earthquake. The substantial progress reached in understanding
 the physics of the electromagnetic and thermal anomalies associated with the earthquake preparation process permitted
 us to create the Lithosphere-Atmosphere-Ionosphere (LAI) coupling model published recently. It shows that
 the observed effects are not independent but present the cause-consequence chain of physical processes and plasma-
 chemical reactions. We try to analyze the seismic data, radon emanation, hydrological anomalies, ground based
 ionosondes network, NOAA/AVHRR Thermal Infrared Irradiance (TIR) anomaly, Intercosmos-19 satellite topside
 sounding and VLF emissions data using the concept of the developed model and existing laboratory and largescale
 active experiments on air ionization. If the observed radon activity is really connected with the earthquake preparation
 process, all other variations of the atmosphere and ionosphere parameters can be explained as a consequence
 of the main physical process air ionization by radon.