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One of the most important public issues in our rapidly ageing society are brain disorders and neurodegenerative diseases. Effective therapies are limited and therefore costs for public health systems rapidly increase in this sector. However, recently the first clinical evidence for a new class of therapies has emerged - ultrasound for the brain. With the first clinical data on ultrasound brain activation just now published, three fascinating options are available to revolutionize non-invasive brain therapy. All three ultrasound therapies currently receive widespread attention from patients and doctors.