Mutation analysis of the BRAF oncogene in juvenile myelomonocytic leukemia
oleh: Andrica C.H. de Vries, Ronald W. Stam, Christian P. Kratz, Martin Zenker, Charlotte M. Niemeyer, Marry M. van den Heuvel-Eibrink
| Format: | Article |
|---|---|
| Diterbitkan: | Ferrata Storti Foundation 2007-11-01 |
Deskripsi
Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative/myelodysplastic disorder associated with mutations in the Ras-Raf-MEK-ERK-signaling pathway. B-Raf plays a central role in this pathway. In 65 screened JMML patients we identified no BRAF mutations and we conclude that this gene is unlikely to play a role in the pathogenesis of JMML.