Kamishoyosan reduces conditioned fear-induced freezing behavior in socially isolated ovariectomized rats
oleh: Nobuaki Egashira, Hikari Iba, Haruna Kuwano, Rikako Kawanaka, Masaki Nagao, Hiroshi Moriyama, Takuya Watanabe, Kaori Kubota, Shutaro Katsurabayashi, Katsunori Iwasaki
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2016-08-01 |
Deskripsi
In the present study, we investigated the effect of kamishoyosan (KSS) on conditioned fear-induced freezing in ovariectomized (OVX) rats. Socially isolated OVX rats showed the longest freezing time among the following four groups: group-housed sham-operated (Sham), isolated Sham, group-housed OVX, and isolated OVX rats. Repeated oral administration of KSS (30–300 mg/kg) reduced conditioned fear-induced freezing in socially isolated OVX rats. The reduction of freezing by KSS was reversed by flumazenil (3 mg/kg) and bicuculline (3 mg/kg). These findings suggest that the GABAA-benzodiazepine receptor complex is involved in the anxiolytic effect of KSS in socially isolated OVX rats.