Rare Acetogenins with Anti-Inflammatory Effect from the Red Alga <i>Laurencia obtusa</i>
oleh: Walied Mohamed Alarif, Sultan Semran Al-Lihaibi, Nahed Obaid Bawakid, Ahmed Abdel-Lateff, Hamdan Salem Al-malky
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2019-01-01 |
Deskripsi
Three new rare C<sub>12</sub> acetogenins (enyne derivatives <b>1</b>⁻<b>3</b>) were isolated from the organic extract obtained from the red alga <i>Laurencia obtusa</i>, collected from the Red Sea. The chemical structures of the isolated compounds were established by spectroscopical data analyses. Potent anti-inflammatory effect of the isolated metabolites was evidenced by inhibition of the release of inflammatory mediators (e.g., TNF-α, IL-1β and IL-6) by employing Human Peripheral Blood Mononuclear Cells (PBMC).