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Introduction: Expanding a spreadsheet model which is used for key engineering calculations for hazardous waste incinerations (HWI) is the most important task in the management of hazardous wastes. The objectives of this study were to develop rigorous calculation procedures for the design and analysis of the incinerator, and incorporate these procedures into an easy-to-use computer program. Findings: In this study, an innovative spreadsheet model application for the HWI is presented in order to provide a convenient method for calculation of flue gas and incinerator design data based on the thermodynamic and the stoichiometric calculations. Conclusions: HWI program was organized into three parts in MS Excel: input data, calculations, and output of the results. A conceptual dataset was used to show the performance of this model using different criteria parameters. The model proved to be an efficient tool to help to engineering calculations for HWI.