Antifungal piperamides from Piper mollicomum Kunth (Piperaceae)
oleh: Herlle Aparecido da Silva, Lydia Fumiko Yamaguchi, Maria Cláudia Marx Young, Clécio Souza Ramos, André Márcio Araújo Amorim, Massuo Jorge Kato, Ronan Batista
| Format: | Article |
|---|---|
| Diterbitkan: | Universidade Estadual Paulista 2018-05-01 |
Deskripsi
The phytochemical study on dichlorometane extracts of leaves, stem and roots of Piper mollicomum Kunth (Piperaceae) led to isolation of the known piperamides tembamide (1), (R)-(-)-tembamide acetate (2) and riparin I (3). Compounds 1 and 2 displayed moderate in vitro antifungal activity against Cladosporium cladosporioides (5.0 μg) and Cladosporium sphaerospermum (1.0 μg) by direct bioautographic analyses and compound 3 was inactive up to 100.0 μg.