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Non-orthogonal multiple access (NOMA) was identified as a technology enabler for the fifth generation and beyond networks, due to the prominent advantages achieved when integrating NOMA with other wireless technologies. In this article, we investigate the interplay between NOMA and generalized space shift keying (GSSK) in a hybrid NOMA-GSSK (N-GSSK) network. Specifically, we provide a comprehensive analytical framework and propose a novel <italic>energy-based N-GSSK detector</italic> for the reliable realization of N-GSSK systems. The proposed receiver is <italic>energy-efficient</italic> and enjoys low complexity, as it exploits the energy of the received signals and does not require the knowledge of NOMA signals. To quantify its efficiency, we further investigate the performance of the proposed detector in terms of pairwise error probability, bit error rate union bound, and achievable rate. The accuracy of the developed mathematical framework is corroborated through Monte-Carlo simulations, which show that N-GSSK outperforms conventional NOMA and GSSK, particularly in terms of spectral efficiency.