Intermediate-state-trapped mutants pinpoint G protein-coupled receptor conformational allostery
oleh: Xudong Wang, Chris Neale, Soo-Kyung Kim, William A. Goddard, Libin Ye
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-03-01 |
Deskripsi
Understanding of GPCR activation is limited as the structural information fails to present the full spectrum of energy landscape. Here, authors establish a series of conformation-biased mutants that represent five conformational states lying along adenosine A2A receptor (A2AR) activation.