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In the signal transduction network, from the perception of stress signals to stress-responsive gene expression, various transcription factors and <i>cis</i>-regulatory elements in stress-responsive promoters coordinate plant adaptation to abiotic stresses. Among the AP2/ERF transcription factor family, group VII ERF (ERF-VII) genes, such as <i>RAP2.12</i>, <i>RAP2.2</i>, <i>RAP2.3</i>, <i>AtERF73</i>/<i>HRE1</i>, and <i>AtERF71</i>/<i>HRE2</i>, are known to be involved in the response to hypoxia in Arabidopsis. Notably, <i>HRE2</i> has been reported to be involved in responses to hypoxia and osmotic stress. In this study, we dissected <i>HRE2</i> promoter to identify hypoxia- and salt stress-responsive region(s). The analysis of the promoter deletion series of <i>HRE2</i> using firefly <i>luciferase</i> and <i>GUS</i> as reporter genes indicated that the −116 to −2 region is responsible for both hypoxia and salt stress responses. Using yeast one-hybrid screening, we isolated HAT22/ABIG1, a member of the HD-Zip II subfamily, which binds to the −116 to −2 region of <i>HRE2</i> promoter. Interestingly, HAT22/ABIG1 repressed the transcription of <i>HRE2</i> via the EAR motif located in the N-terminal region of HAT22/ABIG1. HAT22/ABIG1 bound to the 5′-AATGATA-3′ sequence, HD-Zip II-binding-like <i>cis</i>-regulatory element, in the −116 to −2 region of <i>HRE2</i> promoter. Our findings demonstrate that the −116 to −2 region of <i>HRE2</i> promoter contains both positive and negative <i>cis</i>-regulatory elements, which may regulate the expression of <i>HRE2</i> in responses to hypoxia and salt stress and that HAT22/ABIG1 negatively regulates <i>HRE2</i> transcription by binding to the HD-Zip II-binding-like element in the promoter region.