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Introduction: Oral health related quality of life - United Kingdom (OHQoL-UK) questionnaire is one of the instrument which measure both positive and negative aspect of Oral Health related Quality of Life (OHQoL) at the same time. The aim of this study is to evaluate OHQoL with remaining teeth and other variable using OHQoL-UK questionnaire. Method and Material: This cross-sectional study was done on 150 patients referring to Yazd dental university and Khatamolanbia clinic They were randomly asked to complete OHQoL-UK questionnaire. Number of teeth, present or absence of dental prosthesis (partial or fixed) was examined by the clinician. Then patients completed the OHQoL-UK questionnaire. Results: Sixty one male and 84 female completed the questionnaire. Male have higher mean quality of life score than female (68.8 in male and 67.9 in female) although it was not statistically significant (p=0.519). Increasing age was associated with lower mean quality of life score (p=0.214). Patients with more teeth have higher mean quality of life score (p= 0.002, rs=0.253). Mean quality of life score in patients with partial prosthesis was less than other patients but this relationship was not statistically significant (p=0.563). Patients with fixed prosthesis had higher mean quality of life score than others (p=0.05). Conclusion: According to the effect of dental condition on quality of life and effect of tooth loss on decreasing quality of life, required intervention should be done to improve dental condition and quality of life as a result.