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As one of the first batch of universities selected as members of national “Outstanding Physician Education and Training Program”,Chengdu Medical College has initiated integrated and organ-based remodeling curriculum since 2016, and set up “Comprehensive Basic Medicine problem-based learning(PBL) Course” for the pilot class of outstanding doctors. Through PBL learning, students are guided to comprehensively apply the basic medical knowledge that they have learned to explain clinical phenomena and mechanisms, connecting the preceding and the following, so as to lay a solid foundation for subsequent clinical learning and realize the continuity and systemization of medical knowledge. After several years of practice. Some experience and achieved good teaching effect have been accumulated.