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Post-dryout heat transfer is an important thermal hydraulics phenomenon happening in the loss-of-coolant accident of water-cooled nuclear reactors and the off-design conditions of water-cooled ceramic breeder blanket in fusion reactors. It is necessary to research the flow and heat transfer mechanisms of post-dryout. To economically and comprehensively study on the post-dryout heat transfer characteristics, this work conducted fluid-to-fluid modeling research on water and R-134a data banks by using Buckingham dimensional analysis methodology. In addition, a new interpolation method was developed and verified to make the scaling between the two data banks possible. Finally, a scaling method of post-dryout heat transfer was proposed and assessed by using experimental data. The results showed that the obtained scaling method is reliable in certain conditions.