Altered tRNA dynamics during translocation on slippery mRNA as determinant of spontaneous ribosome frameshifting
oleh: Panagiotis Poulis, Anoshi Patel, Marina V. Rodnina, Sarah Adio
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-07-01 |
Deskripsi
Slippery sequences in mRNA can cause the ribosome to change its reading frame. Using smFRET, Poulis et al. show how reversible fluctuations of peptidyl-tRNA slow down translocation, alter ribosome dynamics, and favor spontaneous ribosome frameshifting.