Structure of the PAPP-ABP5 complex reveals mechanism of substrate recognition
oleh: Russell A. Judge, Janani Sridar, Kathryn Tunyasunvunakool, Rinku Jain, John C. K. Wang, Christna Ouch, Jun Xu, Amirhossein Mafi, Aaron H. Nile, Clint Remarcik, Corey L. Smith, Crystal Ghosh, Chen Xu, Vincent Stoll, John Jumper, Amoolya H. Singh, Dan Eaton, Qi Hao
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2022-09-01 |
Deskripsi
PAPP-A substrate selectivity underlies the tight regulation of IGF signaling. Here, the authors report cryo-EM structures of dimeric PAPP-A in its substrate-free form and in complex with a peptide substrate, which combined with biochemical assays provide a mechanism for PAPP-A substrate binding and selectivity.