Find in Library

<p>Abstract</p> <p>Background</p> <p>Polymorphisms in <it>GSTT1</it>, <it>GSTM1 </it>and <it>GSTP1 </it>impact detoxification of carcinogens by GSTs and have been reported to increase susceptibility to environmentally related health outcomes. Individual factors in arsenic biotransformation may influence disease susceptibility. GST activity is involved in the metabolism of endogenous and exogenous compounds, including catalyzing the formation of arsenic-GSH conjugates.</p> <p>Methods</p> <p>We investigated whether polymorphisms in <it>GSTT1</it>, <it>GSTP1 </it>and <it>GSTM1 </it>were associated with risk of skin lesions and whether these polymorphisms modify the relationship between drinking water arsenic exposure and skin lesions in a case control study of 1200 subjects frequency matched on age and gender in community clinics in Pabna, Bangladesh in 2001–2002.</p> <p>Results and discussion</p> <p><it>GSTT1 </it>homozygous <it>wildtype </it>status was associated with increased odds of skin lesions compared to the null status (OR1.56 95% CI 1.10–2.19). The <it>GSTP1 GG </it>polymorphism was associated with greater odds of skin lesions compared to <it>GSTP1 AA</it>, (OR 1.86 (95%CI 1.15–3.00). No evidence of effect modification by <it>GSTT1</it>, <it>GSTM1 </it>or <it>GSTP1 </it>polymorphisms on the association between arsenic exposure and skin lesions was detected.</p> <p>Conclusion</p> <p><it>GSTT1 wildtype </it>and <it>GSTP1 GG </it>are associated with increased risk of skin lesions.</p>