Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications
oleh: Nan Xiao, Meng Nie, Huanhuan Pang, Bohong Wang, Jieli Hu, Xiangjun Meng, Ke Li, Xiaorong Ran, Quanxin Long, Haijun Deng, Na Chen, Shao Li, Ni Tang, Ailong Huang, Zeping Hu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-03-01 |
Deskripsi
Metabolism changes can modulate immune responses in many contexts, and vice versa. Here the authors associate metabolomic, as well as cytokine and chemokine, data from stratified COVID-19 patients to find that arginine, tryptophan and purine metabolic pathways correlate with hyperproliferation, thus hinting at potential therapeutic targets for severe COVID-19 patients.