Ginsenoside Rg5 prevents apoptosis by modulating heme-oxygenase-1/nuclear factor E2-related factor 2 signaling and alters the expression of cognitive impairment-associated genes in thermal stress-exposed HT22 cells
oleh: Seo-Yun Choi, Kui-Jin Kim, Ji-Hyeon Song, Boo-Yong Lee
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2018-04-01 |
Deskripsi
Our results suggested that thermal stress can lead to activation of hippocampal cell damage and reduction of memory-associated molecules in HT22 cells. These findings also provide a part of molecular rationale for the role of ginsenoside Rg5 as a potent cognitive impairment preventive compound in blocking the initiation of hippocampal damage. Keywords: cognitive impairment, Ginsenoside Rg5, HT22, neuroprotection, thermal stress