Clathrin-nanoparticles deliver BDNF to hippocampus and enhance neurogenesis, synaptogenesis and cognition in HIV/neuroAIDS mouse model
oleh: Gordana D. Vitaliano, Jae K. Kim, Marc J. Kaufman, Christopher W. Adam, Gonzalo Zeballos, Abinaya Shanmugavadivu, Sivan Subburaju, Jay P. McLaughlin, Scott E. Lukas, Franco Vitaliano
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2022-03-01 |
Deskripsi
Vitaliano et al. show in mice that engineered clathrin triskelia (CT) conjugated to BDNF (BDNF-CT) and delivered intranasally increases hippocampal BDNF concentrations 400-fold above that achieved previously with intranasal BDNF alone. They also show that it enhance neurogenesis, synaptogenesis and cognition in a mouse model of HIV/neuroAIDS, highlighting its potential in regenerative medicine.